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Heterogeneity of protein kinase C β 2 expression in lymphoid malignancies
Author(s) -
Decouvelaere AV,
Morschhauser F,
Buob D,
Copin M C,
Dumontet C
Publication year - 2007
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2007.02666.x
Subject(s) - mantle zone , mantle cell lymphoma , lymphoma , follicular lymphoma , marginal zone , lymphoproliferative disorders , germinal center , chronic lymphocytic leukemia , pathology , immunohistochemistry , biology , cancer research , lymphoid hyperplasia , b cell , medicine , antibody , immunology , leukemia
Aims: Protein kinase C (PKC) β is an important regulator of lymphoid survival and its expression has been shown to be altered in lymphomas. The aim was to determine the expression of PKC β 2 in various subtypes of lymphoproliferative diseases by immunohistochemistry. Methods and results: One hundred and forty archival samples representing various subtypes of lymphoproliferative diseases were analysed. Certain subtypes, such as mantle cell, lymphocytic or follicular lymphoma, were found to express PKC β 2 in > 90% of the samples. In follicular lymphomas, the follicular lymphomatous areas were constantly labelled, whereas residual germinal centres remained negative. In follicular hyperplasia, PKC β 2 + cells were found in the mantle and marginal zones. Most angioimmunoblastic T‐cell lymphomas, lymphoblastic T‐cell lymphomas and marginal zone/mucosa‐associated lymphoid tissue (MALT) lymphomas were labelled with anti‐PKC βII antibody, but the pattern of expression was more heterogeneous in these subtypes. A minority of diffuse large B‐cell lymphomas were stained and most plasma cell malignancies were negative. None of the cases of Hodgkin's disease and anaplastic large cell lymphoma expressed PKC β 2 . Conclusions: PKC β 2 expression varies significantly among lymphoproliferative diseases. In our series, the highest level of expression was found in mantle cell lymphomas and chronic lymphocytic lymphoma.