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Endocrine tumours of the gastrointestinal tract—selected topics
Author(s) -
Williams G T
Publication year - 2007
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2006.02570.x
Subject(s) - gastrointestinal tract , endocrine system , medicine , pathology , hormone
This review provides an update on the pathogenesis and histopathological diagnosis of endocrine tumours of the gastrointestinal tract, concentrating on three different varieties whose careful assessment by pathologists is of particular clinical significance. These are the four types of enterochromaffin‐like cell tumour of the gastric corpus, the periampullary somatostatin‐containing D ‐cell tumour of the duodenum, and the frequently chromogranin A‐negative L ‐cell tumour of the appendix and large intestine. In addition, the value of pathological factors in predicting the behaviour of gastrointestinal endocrine tumours and selecting therapy is discussed, and the crucial role of the pathologist in the multidisciplinary team management of these neoplasms is emphasized.