Pathology of fungal infections of the central nervous system: 17 years' experience from Southern India | Zendy

Sundaram C | Zendy; Umabala P | Zendy; Laxmi V | Zendy; Purohit A K | Zendy; Prasad V S S V | Zendy; Panigrahi M | Zendy; Sahu B P | Zendy; Sarathi M V | Zendy; Kaul S | Zendy; Borghain R | Zendy; Meena A K | Zendy; Jayalakshmi S S | Zendy; Suvarna A | Zendy; Mohandas S | Zendy; Murthy J M K | Zendy

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Pathology of fungal infections of the central nervous system: 17 years' experience from Southern India

Author(s) -

Sundaram C,

Umabala P,

Laxmi V,

Purohit A K,

Prasad V S S V,

Panigrahi M,

Sahu B P,

Sarathi M V,

Kaul S,

Borghain R,

Meena A K,

Jayalakshmi S S,

Suvarna A,

Mohandas S,

Murthy J M K

Publication year - 2006

Publication title -

histopathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.626

H-Index - 124

eISSN - 1365-2559

pISSN - 0309-0167

DOI - 10.1111/j.1365-2559.2006.02515.x

Subject(s) - cryptococcosis , zygomycosis , autopsy , aspergillosis , medicine , mycosis , pathology , epidemiology , risk factor , diabetes mellitus , central nervous system , retrospective cohort study , biopsy , pathogenesis , granuloma , dermatology , antifungal , immunology , amphotericin b , endocrinology

Aims: To describe the pathology of central nervous system (CNS) fungal infections with particular reference to India. Methods and results: This was a retrospective study from 1988 to 2004 constituting 130 cases. The diagnosis was based on morphology of biopsy/autopsy material. These included aspergillosis ( n = 73), zygomycosis ( n = 40), cryptococcosis ( n = 2), rhodotorulosis ( n = 1), candidiasis ( n = 5), maduramycosis ( n = 1), pheohyphomycosis ( n = 3) and mixed infections ( n = 5). Predisposing risk factors were present in 49 (38%) patients only. The majority of the patients were immunocompetent. The commonest risk factor was diabetes mellitus, the commonest route of infection was from a contiguous site and the commonest pathology was granuloma. Culture positivity was seen in only 31%. Conclusion: Environmental factors in tropical countries such as India play a significant role in the pathogenesis of CNS fungal infections.

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