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Clinical significance of CK5/6 and PTEN protein expression in patients with bilateral breast carcinoma
Author(s) -
Piekarski J H,
Biernat W
Publication year - 2006
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2006.02482.x
Subject(s) - pten , immunohistochemistry , cytokeratin , medicine , progesterone receptor , breast cancer , proportional hazards model , breast carcinoma , hazard ratio , oncology , carcinoma , clinical significance , pathology , cancer research , cancer , biology , estrogen receptor , apoptosis , biochemistry , confidence interval , pi3k/akt/mtor pathway
Aims: To assess the expression of cytokeratin (CK) 5/6 in bilateral breast cancers and to assess the relationship between its expression and other prognostic variables, as well as between CK5/6 expression and patients' survival. Methods and results: The expression of CK5/6, PTEN protein, oestrogen receptor, progesterone receptor, p53 and c‐erbB‐2 protein were evaluated by immunohistochemistry in 88 primary breast cancers diagnosed in 44 women. To assess the prognostic value of studied factors, Cox regression analysis was performed. Expression of CK5/6 was found in 23 of 88 primary breast carcinomas (23/88; 26%). The hazard ratio of development of distant metastasis in patients in whom at least one cancer was CK5/6+ was 99.8 ( P = 0.037) and in patients with at least one carcinoma with reduced PTEN expression it was 10.8 ( P = 0.044). CK5/6 expression was correlated with absence of oestrogen ( P < 0.0001) and progesterone receptors ( P < 0.0001) and very strong expression of p53 ( P < 0.05). Reduced PTEN expression was correlated with presence of axillary metastases ( P < 0.01), with very strong expression of c‐erbB‐2 ( P < 0.05) and with reduced expression of oestrogen receptor ( P < 0.05). Conclusions: Analysis of expression of CK5/6 and PTEN protein in bilateral breast carcinomas may be of value in clinical practice and warrant further studies.