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Laboratory handling and histology reporting of breast specimens from patients who have received neoadjuvant chemotherapy
Author(s) -
Pinder S E,
Provenzano E,
Earl H,
Ellis I O
Publication year - 2007
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2006.02419.x
Subject(s) - medicine , chemotherapy , breast carcinoma , lymph , histology , neoadjuvant therapy , surgical pathology , breast cancer , carcinoma , oncology , pathology , radiology , cancer
Neoadjuvant chemotherapy is increasingly being offered to patients with invasive breast carcinoma but surgical excision specimens following such therapy may be difficult to interpret in the pathology laboratory, both macroscopically and histologically. We provide here some guidelines for handling such postneoadjuvant chemotherapy samples and describe the histopathological features which may be encountered in both the breast and lymph nodes received. We also present a brief review of the literature and suggest a simple method for quantifying the degree of response to neoadjuvant chemotherapy in both the primary breast carcinoma and the lymph nodes.