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A clinicopathological study of nodal marginal zone B‐cell lymphoma. A report on 21 cases
Author(s) -
TraverseGlehen A,
Felman P,
CalletBauchu E,
Gazzo S,
Baseggio L,
Bryon P A,
Thieblemont C,
Coiffier B,
Salles G,
Berger F
Publication year - 2006
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2005.02309.x
Subject(s) - lymphoma , pathology , marginal zone , bone marrow , medicine , b symptoms , lymphatic system , stage (stratigraphy) , spleen , b cell , biology , immunology , antibody , paleontology
Aims : To report the clinicopathological findings of 21 cases of primary nodal marginal zone B‐cell lymphoma (NMZL). NMZL is a recently characterized lymphoma and few series have been published. Methods and results : The clinical data were characteristic of a disseminated disease at presentation: presence of peripheral and abdominal lymph nodes, bone marrow involvement (62%), disease stage III and IV (76%), elevated lactate dehydrogenase (LDH) (48%). Other features included peripheral blood involvement (23%), anaemia (24%), thrombocytopenia (10%) and presence of serum M component (33%), while the previously reported association with hepatitis C virus and cryoglobulinaemia was not found. Relapses were frequent but the majority of patients receiving chemotherapy had a good initial response. Morphological features were heterogeneous and there were some differences compared with other marginal zone B‐cell lymphomas (MZL). Pure monocytoid B‐cell lymphomas were rare (10%) but a minor component of monocytoid B cell was observed more frequently (23%). Plasmacytoid or plasmacytic differentiation was a very common feature (61%). Large cells and a high mitotic count were also frequent (57%). Conclusion : NMZL can be distinguished from splenic MZL and extranodal MZL by its aggressive morphology and disseminated disease at presentation.