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Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS‐CHOP transcript
Author(s) -
De Cecco L,
Gariboldi M,
Reid J F,
Lagonigro M S,
Tamborini E,
Albertini V,
Staurengo S,
Pilotti S,
Pierotti M A
Publication year - 2005
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2005.02064.x
Subject(s) - liposarcoma , myxoid liposarcoma , pathology , biology , epithelioid cell , fusion gene , chop , immunohistochemistry , epithelioid sarcoma , gene , sarcoma , medicine , lymphoma , genetics
Aims : To describe a tumour with morphological and immunophenotypic characteristics of epithelioid variant of pleomorphic liposarcoma. Pleomorphic liposarcoma is a very rare variant of liposarcoma defined morphologically by the presence of pleomorphic lipoblasts showing peculiar epithelial‐like features that can be confused with primary or metastatic carcinoma. Methods and results : Molecular analysis demonstrated for the first time the presence of FUS‐CHOP transcript in this liposarcoma variant. Microarray analysis revealed a gene expression profile related to a more aggressive tumour type when compared with other myxoid/round cell liposarcomas. Conclusions : The present data show that the epithelioid variant of pleomorphic liposarcoma represents a further variant of myxoid liposarcoma sharing the FUS‐CHOP fusion transcript but carrying a distinct expression profile, in keeping with its aggressive clinical course.