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Histological indicators of prognosis in glioblastomas: retinoblastoma protein expression and oligodendroglial differentiation indicate improved survival
Author(s) -
Hilton D A,
Penney M,
Pobereskin L,
Sanders H,
Love S
Publication year - 2004
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2004.01887.x
Subject(s) - retinoblastoma , oligodendroglial tumor , pathology , protein expression , biology , immunohistochemistry , retinoblastoma protein , glioblastoma , medicine , oncology , cancer research , oligodendroglioma , cell cycle , astrocytoma , gene , genetics , cancer
Aim: To assess the potential prognostic significance of a range of molecular and morphological parameters in glioblastomas that can be applied in the setting of a routine diagnostic neuropathology laboratory. Methods and results: A consecutive series of 107 adult glioblastomas were studied. Retinoblastoma and deleted‐in‐colon cancer (DCC) protein expression were assessed using immunocytochemistry and chromosome 10 loss by in‐situ hybridization. Loss of retinoblastoma expression was associated with a worse outcome, which appeared to be independent of age. There was no significant association between chromosome 10 loss or DCC protein expression and survival. Survival was significantly increased in the 5% of patients whose tumours had focal morphological features suggesting oligodendroglial differentiation. Conclusions: Glioblastomas containing areas of oligodendroglial differentiation or showing widespread immunocytochemical expression of retinoblastoma protein have a better prognosis than those without these features.