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Post‐transplant T‐cell lymphoproliferative disorder/T‐cell lymphoma: a report of three cases of T‐anaplastic large‐cell lymphoma with cutaneous presentation and a review of the literature
Author(s) -
Coyne J D,
Banerjee S S,
Bromley M,
Mills S,
Diss T C,
Harris M
Publication year - 2004
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2004.01847.x
Subject(s) - anaplastic large cell lymphoma , lymphoma , pathology , immunophenotyping , cd30 , lymphoproliferative disorders , large cell , medicine , transplantation , post transplant lymphoproliferative disorder , t cell lymphoma , epstein–barr virus , immunology , virus , antigen , rituximab , cancer , adenocarcinoma
Aims: To report the clinical, pathological and immunohistochemical features of three cases of post‐transplant T‐cell lymphoproliferative disorder (T‐PTLD) T‐cell lymphoma with primary cutaneous presentation. Methods and results: Three cases of primary cutaneous post‐transplantation anaplastic large‐cell lymphomas occurred in renal transplant recipients and were shown to display a T‐cell immunophenotype; all were ALK 1 protein and EMA negative and two were Epstein–Barr virus positive using in‐situ hybridization. Two displayed a CD4+ phenotype, two were focally CD56+ and all three were negative for the cytolytic enzyme granzyme B. In two cases monoclonality was established by T‐cell receptor gene rearrangement study. All presented with nodular cutaneous involvement and all were ultimately fatal. Conclusion: T‐PTLDs are uncommon histological subtypes both in a general context and associated with cutaneous presentation. Our findings suggest clinicopathological and immunophenotypic similarities to primary cutaneous anaplastic large‐cell lymphoma but with a progressive clinical behaviour similar to previously reported T‐PTLD and to systemic nodal ALK– anaplastic large‐cell lymphoma.