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Pyothorax‐associated lymphoma (PAL): a western case with marked angiocentricity and review of the literature
Author(s) -
Androulaki A,
Drakos E,
Hatzianastassiou D,
Vgenopoulou S,
Gazouli M,
Korkolopoulou P,
Patsouris E,
Dosios T
Publication year - 2004
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2004.01737.x
Subject(s) - lymphoma , pathology , medicine , primary effusion lymphoma , immunohistochemistry , diffuse large b cell lymphoma , working formulation , virus , non hodgkin's lymphoma , immunology
Aims : To report a case of pyothorax‐associated lymphoma in a non‐immunocompromised 78‐year‐old man with a 45‐year history of tuberculous pleuritis and left pleural effusion. Pyothorax‐associated lymphoma is a high‐grade non‐Hodgkin's lymphoma occurring in 2% of patients with long‐standing tuberculous pleuritis and pyothorax. Pyothorax‐associated lymphoma is frequently Epstein–Barr virus (EBV)‐associated, mainly reported in Japan but exceedingly rare in western countries. Methods and results : Histology revealed a high‐grade, diffuse large B‐cell lymphoma with immunoblastic and plasmacytoid features and marked angiocentricity with focal destruction of the vessel walls. Immunohistochemistry revealed a post germinal B‐cell phenotype. RNA in‐situ hybridization and molecular analysis showed a latent EBV infection and absence of human herpes virus‐8 (HHV‐8). Conclusions : Pyothorax‐associated lymphoma represents a rare but distinctive type of diffuse large B‐cell lymphoma, with characteristic clinico‐epidemiological, immunohistological, and biological features.