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Dermal spindle cell lipoma: plexiform and nodular variants
Author(s) -
ZELGER B.W.H.,
ZELGER B.G.,
PLÖRER A.,
STEINER H.,
FRITSCH P.O.
Publication year - 1995
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1995.tb00324.x
Subject(s) - pathology , anatomy , lipoma , vimentin , biology , basal lamina , stromal cell , medicine , immunohistochemistry , ultrastructure
We report on eleven cases of a distinctive dermal spindle cell lipoma characterized by a mixture of mature adipocytes and spindle‐shaped cells in a fibromucinous background. Six lesions showed a moderately well circumscribed plexiform pattern, five a well demarcated nodular pattern with compression of surrounding connective tissue and prominent stromal fibrosis. Clinically, the plexiform type mostly occurred in the thigh‐groin‐buttock area and the nodular type in the head‐neck or acral location. While plexiform lesions were predominantly seen in middle‐aged females, nodular types occurred in young adults of either sex. No recurrence was seen in five patients with follow‐up. The tumour cells were vimentin positive and a thin cytomplasmic rim of S‐100 protein positivity was seen in mature adipocytes. Ultrastructural studies revealed lipoblastic differentiation of spindle‐shaped cells with lipid droplets and basal lamina formation. Dermal spindle cell lipomas seem to be the dermal counterpart of the most subcutaneously located spindle cell lipoma.