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Pancreatic metaplasia of the human gastric mucosa is associated with high expression of transforming growth factor α but not of epidermal growth factor
Author(s) -
STACHURA J.,
KONTUREK J.,
URBAŇZYK K.,
BOGDAL J.,
DOMSCHKE W.
Publication year - 1995
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1995.tb00321.x
Subject(s) - epidermal growth factor , gastric mucosa , immunostaining , transforming growth factor , pathology , metaplasia , immunohistochemistry , intestinal metaplasia , biology , growth factor , tgf alpha , stomach , medicine , endocrinology , receptor
Pancreatic acinar metaplasia of the gastric mucosa is a newly recognized entity. Its physiological relevance and association with other pathological conditions in the stomach remain to be elucidated. We studied by immunohistochemistry the expression of growth markers in the gastric mucosa in biopsies from 15 patients with recognized pancreatic metaplasia. Pancreatic metaplasia (both acinar and dispersed forms) was found in routine paraffin sections and confirmed by strong lipase immunoreactivity. In parallel paraffin sections we performed immunostaining for epidermal growth factor (EGF), transforming growth factor‐α (TGFα) and epidermal growth factor receptor (EGFr) using a biotin streptavidin method. Strong expression of TGFα but only weak expression of EGF was noted within metaplastic mucosa. EGFr was strongly expressed, not only in areas of pancreatic metaplasia but also in the surrounding gastric mucosa.