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Immunohistochemical detection of bcl‐2 protein in thymoma
Author(s) -
BROCHERIOU I.,
CARNOT F.,
BRIERE J.
Publication year - 1995
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1995.tb00217.x
Subject(s) - thymoma , immunohistochemistry , pathology , medullary cavity , staining , medulla , biology , medicine , anatomy
The protooncogene bcl ‐2 encodes a protein that inhibits apoptosis. The protein is expressed in most epithelial cells of the fetal thymic medulla but, to the best of our knowledge, no data are available on bcl‐2 expression in thymoma. Expression of bcl‐2 protein was analysed in 30 cases of thymoma by immunohistological staining of paraffin‐embedded tissue. All cases were examined and classified according to the Salyer and Eggleston and the Müller‐Hermelink classification. In four cases, the protooncogene bcl ‐2 was abnormally expressed in spindle cells of pure medullary thymoma, whereas the non‐spindle cells in mixed and in cortical thymoma were negative. All the lymphocytes were also strongly positive in medullary thymoma while a few lymphocytes showed light staining in other thymomas.