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Intraosseous secondary calcium salt crystal deposition: an artefact of acid decalcification
Author(s) -
KEEN C.E.,
CROCKER P.R.,
BRADY K.,
BUK S.J.A.,
LEVISON D.A.
Publication year - 1995
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1995.tb00027.x
Subject(s) - bone decalcification , brushite , calcium , calcium pyrophosphate , chemistry , calcium oxalate , salt (chemistry) , crystallization , pyrophosphate , crystal (programming language) , mineralogy , calcium salts , dentistry , biochemistry , medicine , organic chemistry , enzyme , computer science , programming language
We previously observed, in decalcificated bone specimens, intraosseous crystal deposits with morphological and analytical similarity to calcium pyrophosphate dihydrate. We have now been able, by a combination of more detailed morphological studies of these and similar cases, and by infrared spectroscopy in three cases, to show that this is, in fact deposition of the secondary calcium salts brushite and monetite, occurring as an artefact during formic acid decalcification. Our earlier postulate of bone as an additional primary crystallization site for calcium pyrophosphate dihydrate is effectively disproved. This artefact deserves wider recognition.