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Nodular transformation of splenic red pulp due to carcinomatous infiltration. A diagnostic pitfall
Author(s) -
FAKAN F.,
MICHAL M.
Publication year - 1994
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1994.tb01575.x
Subject(s) - pathology , red pulp , spleen , immunostaining , infiltration (hvac) , malignant transformation , autopsy , medicine , histopathological examination , stomach , carcinoma , immunohistochemistry , physics , thermodynamics
Autopsy of three women dying of disseminated carcinoma of stomach, colon, and breast, respectively, revealed a grossly unremarkable spleen. Microscopic examination demonstrated a nodular transformation of the red pulp, simulating a follicular lymphoma. Immunostaining revealed dissociated carcinomatous cells between the nodules, and this was thought to be the cause of the nodular transformation.