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Epstein‐Barr virus in cutaneous lymphomatoid granulomatosis
Author(s) -
ANGEL C.A.,
SLATER D.N.,
ROYDS J.A.,
NELSON S.N.P.,
BLEEHEN S.S.
Publication year - 1994
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1994.tb01373.x
Subject(s) - lymphomatoid granulomatosis , lymphomatoid papulosis , etiology , pathology , virus , epstein–barr virus , medicine , disease , epstein–barr virus infection , immunology , lymphoma , mycosis fungoides
Epstein‐Barr virus (EBV) has been associated with various extra‐cutaneous lymphoproliferative diseases and it has been suggested that EBV may have a similar aetiological role in the skin. In this study, 10 biopsies from 7 cases of primary cutaneous lymphomatoid granulomatosis have been analyzed, using in situ hybridisation, for the presence of EBV encoded RNAs (EBER‐1 and EBER‐2). Only one case showed positive staining with the EBER probes and it is concluded that, in the skin, the relationship between EBV and lymphomatoid granulomatosis is variable. The role of EBV as an aetiological agent in primary cutaneous lymphomatoid granulomatosis appears less important than in primary respiratory disease.