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c‐ erb B‐3 protein expression in human breast cancer: comparison with other tumour variables and survival
Author(s) -
QUINN C.M.,
OSTROWSKI J.L.,
LANE S.A.,
LONEY D.P.,
TEASDALE J.,
BENSON E.A.
Publication year - 1994
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1994.tb01324.x
Subject(s) - immunohistochemistry , breast cancer , lymph node , medicine , monoclonal antibody , pathology , mammary gland , cancer , antibody , oncology , biology , cancer research , immunology
c‐ erb B‐3 protein expression was investigated immunohistochemically in a series of 97 malignant breast tumours using the monoclonal antibody RTJ1. Twenty‐eight cases (28.8%) showed c‐ erb B‐3 overexpression, 31 cases (32%) showed normal levels of c‐ erb B‐3 and 38 cases (39.2%) were c‐ erb B‐3 negative. c‐ erb B‐3 overexpression was positively but not significantly related to negative lymph node status and survival over a 10‐year follow‐up period.