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Gastric epithelial atypia complicating hepatic arterial infusion chemotherapy
Author(s) -
KWEE W.S.,
WILS J.A.,
SCHLANGEN J.,
NUYENS C.M.,
ARENDS J. W.
Publication year - 1994
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1994.tb01294.x
Subject(s) - atypia , medicine , chemotherapy , floxuridine , pathology , fluorouracil
Severe gastric lesions developed in five patients during hepatic arterial infusion chemotherapy employing 5‐fluorouracil plus either leucovorin or mitomycin C. Ulceration with marked epithelial atypia was observed with striking structural distortion and cellular pleomorphism of the affected gastric mucosa. These features should be considered to be a complication of such treatment and should not be misinterpreted as malignancy.