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Solid cell nests of the thyroid in medullary thyroid carcinoma
Author(s) -
OZAKI O.,
ITO K.,
FUJISAWA T.,
KAWANO M.,
IWABUCHI H.,
KITAMURA Y.,
SUGINO K.,
MIMURA T.
Publication year - 1994
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1994.tb01274.x
Subject(s) - calcitonin , thyroid , pathology , medullary cavity , thyroglobulin , medullary carcinoma , thyroid carcinoma , immunohistochemistry , medicine , chromogranin a
Solid cell nests of the thyroid gland were studied in 44 patients with medullary thyroid carcinoma. In 10 (22.7%) patients, solid cell nests were revealed in the vicinity of tumour foci (five cases) or in the contralateral thyroid lobe and isthmus (four cases); in one case the location was indeterminate. In all seven cases in which immunohistochemical studies were carried out, solid cell nests showed negative staining for thyroglobulin, calcitonin and chromogranin A, findings which were distinct from those in medullary thyroid carcinoma. It is therefore suggested that solid cell nests of the thyroid are not precursors of this tumour.