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Malignant lymphoma of the urethra: report of a case with detection of Epstein–Barr virus genome in the tumour cells
Author(s) -
OHSAWA M.,
MISHIMA K.,
SUZUKI A.,
HAGINO K.,
DOI J.,
AOZASA K.
Publication year - 1994
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1994.tb00570.x
Subject(s) - lymphoma , virus , epstein–barr virus , antibody , in situ hybridization , antigen , pathology , genome , urethra , biology , herpesviridae , gammaherpesvirinae , virology , medicine , immunology , gene , viral disease , gene expression , anatomy , genetics
We report a primary non‐Hodgkin's B‐cell lymphoma of the urethra in a 78‐year‐old female. Serum antibodies for Epstein–Barr virus (EBV) were negative, but there was a 40‐fold increase in antibodies to EBV‐associated nuclear antigen. Using PCR and in situ hybridization techniques, EBV genome was found in the tumour cell nuclei.