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Florid basal cell hyperplasia of the prostate
Author(s) -
VOORDE W. VAN DE,
BALDEWIJNS M.,
LAUWERYNS J.
Publication year - 1994
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1994.tb00535.x
Subject(s) - myoepithelial cell , pathology , cytokeratin , hyperplasia , atypia , biology , immunohistochemistry , basal (medicine) , prostate , lesion , cancer , medicine , endocrinology , genetics , insulin
Florid basal cell hyperplasia of the prostate is an uncommon proliferative condition, most often associated with adenomatous hyperplasia. It is considered a benign lesion although confusion with prostatic cancer is possible when one is not familiar with the histopathological appearance. We report another two cases of the glandular type of basal cell hyperplasia with immunohistochemical findings. Both lesions were composed of crowded and rather small glands with piling up of basaloid cells. They showed immunohistochemical positivity for high molecular weight cytokeratin 34βE12, confirming their relationship with basal cells. We detected focal positivity of these basal cells for α‐smooth muscle actin, suggesting myoepithelial differentiation. Paucity of actin‐positive smooth muscle cells in the stroma was noticed. One of the lesions showed some mild cytological atypia with prominent nucleoli and increased mitotic activity.