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Emergence of α5β1 fibronectin‐ and αvβ3 vitronectin‐receptor expression in melanocytic tumour progression
Author(s) -
DANEN E.H.J.,
BERGE P.J.M. TEN,
MUIJEN G.N.P. VAN,
VAN'T HOFGROOTENBOER A.E.,
BRÖCKER E.B.,
RUITER D.J.
Publication year - 1994
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1994.tb00517.x
Subject(s) - vitronectin , fibronectin , pathology , medicine , receptor , cancer research , expression (computer science) , biology , microbiology and biotechnology , extracellular matrix , computer science , programming language
Cell adhesion is crucial in the process of tumour progression. As integrins are important receptor molecules involved in cell adhesion, we studied the distribution of the α1‐6, αv, αIIb, β1, β3, and β4 integrin subunits in tissue sections of common naevocellular naevi ( n =22), dysplastic naevi (16), thin (24) and thick primary cutaneous melanomas (28), and melanoma metastases (25). We found correlated expression of α1/α2, of α4/α5/β3, and of α6/β4. Decrease of α6 and β4, and increase of α4 and αv were found to be correlated with melanoma progression. Furthermore, expression of α5 and β3 was detected only in primary melanoma and melanoma metastasis. Our findings indicate that during melanoma progression alterations in integrin expression occur, the most striking being emergence of α5β1 fibronectin and αvβ3 vitonectin receptor.