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Cytoplasmic c‐ erb B‐2 protein expression correlates with survival in Dukes' B colorectal carcinoma
Author(s) -
KAY E.W.,
MULCAHY H.,
WALSH C. BARRY,
LEADER M.,
O'DONOGHUE D.
Publication year - 1994
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1994.tb00007.x
Subject(s) - colorectal cancer , staining , carcinoma , immunohistochemistry , pathology , proportional hazards model , survival analysis , adenocarcinoma , population , medicine , biology , cancer , gastroenterology , environmental health
The prognostic significance of c‐ erb B‐2 expression was studied in paraffin wax embedded colorectal cancer tissue using a monoclonal antibody. One hundred and sixty‐four patients with Dukes' B disease were studied. Membranous staining was not detected in any case. Cytoplasmic c‐ erb B‐2 staining was seen in 55 cancers (33.5%). Cytoplasmic taining was unrelated to patient age ( P = 0.31), sex ( P = 0.69), tumour site ( P = 0.69), size ( P = 0.57), histological grade ( P = 0.42) or ploidy status ( P = 0.21) but was found more frequently in obstructing cancers ( P = 0.03). Mean follow up of the patient population was 6.3 years. Five‐year‐survival estimated by the Kaplan‐Meier life‐table method was 47% for those with cytoplasmic c‐ erb B‐2 staining and 77% for those without (log rank analysis; P ? 0.0001). Stepwise regression analysis identified c‐ erb B‐2 staining (relative risk, 2.51; P = 0.0005) and bowel obstruction (relative risk, 1.99; P = 0.015) as independent predictors of survival. It is suggested that cytoplasmic c‐ erb B‐2 expression may provide a useful marker of tumour behaviour in Dukes' B colorectal cancer.