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Gold in the dermis following chrysotherapy: histopathology and microanalysis
Author(s) -
KEEN C.E.,
BRADY K.,
KIRKHAM N.,
LEVISON D.A.
Publication year - 1993
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1993.tb01219.x
Subject(s) - microanalysis , dermis , histopathology , pathology , gold standard (test) , electron probe microanalysis , colloidal gold , dermatology , chemistry , medicine , materials science , nanotechnology , mineralogy , electron microprobe , radiology , organic chemistry , nanoparticle
Paraffin‐embedded sections of skin from patients with rheumatoid arthritis treated with gold who had developed skin rashes were examined by light microscopy and scanning electronmicroscopy with microanalysis. Sparse, small, brown or black granules in plump, often elongated cells in the dermis were shown to contain gold by energy dispersive X‐ray microanalysis. These cells expressed some macrophage markers. The amount of gold present showed some correlation with the total gold dose. Gold was not confined to lesional skin. In one case where uninvolved skin was examined, more gold was found there than in lesional skin.