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The cytological spectrum of the monocytoid B‐cell reaction: recognition of its large cell type
Author(s) -
PLANK L.,
HANSMANN M.L.,
FISCHER R.
Publication year - 1993
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1993.tb00490.x
Subject(s) - cell , spectrum (functional analysis) , pathology , chemistry , biology , medicine , physics , genetics , quantum mechanics
To analyse the cytological features of benign monocytoid B‐cells, we investigated, histologically and immunohisto‐chemically, 78 reactive lymphadenopathies expressing monocytoid B‐cell reactions. Within a broad cytological spectrum of reactive monocytoid B‐cells, two cytological types can be recognized: 1 the common type composed of medium‐sized cells with irregular or bean‐shaped nuclei and inconspicuous nucleoli, and 2 the large cell type composed of cells considered to represent large transformed monocytoid B‐cells, with less pleomorphic round nuclei with vesicular chromatin and moderately basophilic, prominent nucleoli. In between these variants transitional forms showing evolution to large transformed monocytoid B‐cells occurred. While monocytoid B‐cell reactions in 70.5% of all cases were composed predominantly of the common type of monocytoid B‐cells, in 29.5% of cases the large transformed cells prevailed. The two distinctive cytological types of reactive monocytoid B‐cells, seem to have their neoplastic counterparts in monocytoid B‐cell lymphoma, including its large cell variant.