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Pigmented ganglioneuroblastoma: a tumour cell ‘storage disease’?
Author(s) -
O'DOWD G.M.,
GAFFNEY E.F.
Publication year - 1993
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1993.tb00183.x
Subject(s) - ganglioneuroblastoma , melanin , intracellular , pathology , lipofuscin , cell , ultrastructure , biology , chemistry , medicine , microbiology and biotechnology , cell culture , biochemistry , neuroblastoma , ganglioneuroma , genetics
We report a composite nodular ganglioneuroblastoma, distinctive for the presence of coarsely granular black intracellular pigment, which was histochemically indistinguishable from.melanin. Ultrastructurally, the pig‐ment was resolved as numerous heterogeneous lyso‐somes, containing material compatible with oxidized lipid residues, the accumulation of which may reflect. acquired lysosomal dysfunction in individual tumour cells‐a tumour cell ‘storage disease’.