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A histological and electronmicroscopic study of intracorneal melanin in benign and malignant melanocytic lesions
Author(s) -
JONES H.,
ALLIBONE R.O.,
CLARKE T.
Publication year - 1993
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1993.tb00097.x
Subject(s) - melanin , atypia , pathology , melanoma , melanocytic nevus , feature (linguistics) , medicine , dermatology , biology , nevus , cancer research , linguistics , philosophy , genetics
Intracorneal melanin is a feature quite frequently encountered in a range of melanocytic lesions, yet has rarely been described in the literature. We examined a variety of melanocytic lesions with increasing degrees of melanocytic atypia for this feature. The distribution and amount of intracorneal melanin is described and it was shown to be entirely within keratinocytes. In general, the amount of intracorneal melanin was related to increasing melanocytic atypia and was typically distributed in a disorderly fashion in malignant lesions.