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Post‐transplant lymphoproliferative disorders: a morphologic, phenotypic and genotypic spectrum of disease
Author(s) -
SWERDLOW S.H.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb01007.x
Subject(s) - lymphoproliferative disorders , immunosuppression , monoclonal , lymphoma , genotype , pathology , immunology , virus , transplantation , epstein–barr virus , disease , monoclonal antibody , phenotype , polyclonal antibodies , biology , medicine , genetics , antibody , gene
The post‐transplant lymphoproliferative disorders represent a spectrum of life‐threatening, generally Epstein‐Barr virus‐associated lymphoid proliferations which occur in the setting of exogenous immunosuppression following organ transplantation. Histopathological, phenotypic, genotypic and Epstein‐Barr virus studies have revealed a broad range of abnormalities. At one end of the spectrum, they are polymorphic polyclonal proliferations with many features of a florid viral infection and, at the other end, they are monomorphic and monoclonal which would fulfill the criteria for a conventional non‐Hodgkin's lymphoma, usually of B‐cell type. Some patients have both polyclonal and monoclonal lesions and some have two or more monoclonal populations. Finally, because of the varied appearances, different classification schemes have been developed with reported prognostic implications.