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Bone marrow granulomas in acute myeloid leukaemia following interleukin 2 and lymphokine‐activated killer cells
Author(s) -
O'BRIEN D.V.,
BOON A.P.,
BOUGHTON B.J.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb00969.x
Subject(s) - medicine , hematology , queen (butterfly) , university hospital , biology , hymenoptera , botany
Granulomas are thought to represent an immune reaction to antigenic stimulation. Bone marrow granulomas are uncommon, but in the following case report we show their transient appearance after interleukin 2 (IL-2) and autologous lymphokine-activated killer cell therapy. This is a previously unreported association, and may implicate IL-2 in the pathogenesis of granulomas.