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Carcinoma of the thyroid at a young age—a review of 23 patients
Author(s) -
MIZUKAMI Y.,
MICHIGISHI T.,
OMURA A.,
HASHIMOTO T.,
NOGUCHI M.,
MATSUBARA F.,
WATANABE K.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb00918.x
Subject(s) - medicine , thyroid carcinoma , thyroid , lung , carcinoma , stage (stratigraphy) , radiation therapy , aneuploidy , papillary carcinoma , thyroiditis , oncology , gastroenterology , pathology , paleontology , biochemistry , chemistry , gene , chromosome , biology
Twenty‐three children and adolescents with thyroid carcinoma who were 20 years old or younger at the time of initial treatment were followed for a mean time of 9.5 years. Of the tumours, 21 were papillary and two follicular carcinomas. The majority (91%) of the 23 cases showed extra‐thyroidal extension of the tumour. An association with chronic thyroiditis was observed in 30% of the cases. There was no history of irradiation of the head and neck in any patients. Relapse occurred in eight patients, lung metastases in two and local recurrences in six; one patient died from lung metastases 3 months after initial treatment. Male patients, advanced stage of tumour, less differentiated histological features and DNA aneuploidy were associated with a higher frequency of relapse. The prognosis of thyroid carcinomas in children and adolescents is not so good as is generally believed.