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Adenomatoid tumours: a mucin histochemical and immunohistochemical study
Author(s) -
GODDARD M.J.,
GRANT J.W.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb00917.x
Subject(s) - immunohistochemistry , staining , enolase , polyclonal antibodies , pathology , biology , mucin , antigen , vimentin , monoclonal antibody , microbiology and biotechnology , hyaluronidase , keratin , antibody , enzyme , medicine , immunology , biochemistry
We have examined 16 cases of adenomatoid tumour using a panel of monoclonal and polyclonal antibodies and also stained them for the presence of hyaluronidase‐sensitive alcianophilic material. Fourteen cases expressed cytokeratins and a proportion of these also expressed S‐100 protein, neuron‐specific enolase, vimentin, and human milk fat globule protein 2. The same 14 cases also showed hyaluronidase‐sensitive staining with alcian blue. No expression of factor VIII‐related antigen was seen in these cases. We conclude that this provides further evidence of a mesothelial origin of these tumours. The remaining two cases did not express cytokeratins and no hyaluronidase‐sensitive staining with alcian blue was seen. They did however express factor VIII‐related antigen. Although they were morphologically indistinguishable from the other 14 cases, we suggest that they should be more properly regarded as angiomas.