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Frequent expression of haemopoietic and non‐haemopoietic antigens by neoplastic plasma cells: an immunohistochemical study using formalin‐fixed, paraffin‐embedded tissue
Author(s) -
PETRUCH U.R.,
HORNY H.P.,
KAISERLING E.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb00913.x
Subject(s) - antigen , pathology , plasmacytoma , immunohistochemistry , antibody , biology , plasma cell myeloma , haematopoiesis , cytokeratin , microbiology and biotechnology , bone marrow , immunology , multiple myeloma , stem cell , medicine , genetics
There is increasing evidence that neoplastic plasma cells express various haemopoietic and non‐haemopoietic antigens. Since this issue could raise problems in diagnostic histopathology, we have investigated 51 cases of multiple myeloma (plasmacytoma) systematically with a broad panel of antibodies applicable on paraffin‐embedded and mildly decalcified tissue. In approximately 90% of the cases the neoplastic plasma cells reacted with at least one antibody detecting haemopoietic antigens: MB2 (75%), DF‐T1/CD 43 (59%), UCHL1/CD 45RO (47%), Ki‐B3 (41%), anti‐LCA/CD 45 (40%), L26/CD 20 (26%), 4KB5/CD 45RA (18%), Ber H2/CD 30 (10%), anti‐neutrophil elastase (4%), anti‐Leu‐7/CD 57 (8%), Dako‐M1/CD 15 (2%), KP1/CD 68 (2%) and anti‐glycoprotein IIIa (2%). In approximately 70% of the cases the cells reacted with antibodies against non‐haemopoietic antigens: anti‐epithelial membrane antigen (65%), BMA120 (53%), anti‐vimentin (44%), anti‐pan‐cytokeratin/KL1 (8%), anti‐carcino‐embryonic antigen (6%) and HMB45 (6%). Lack of awareness of the frequent expression of both haemopoietic and non‐haemopoietic antigens by neoplastic plasma cells could lead to mis‐diagnosis of plasmacytomas as malignant lymphomas or even as carcinomas or sarcomas.