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The lymphoepithelial lesion of gastric low‐grade B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT): an ultrastructural study
Author(s) -
PAPADAKI L.,
WOTHERSPOON A.C.,
ISAACSON P.G.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb00425.x
Subject(s) - malt lymphoma , pathology , lymphatic system , ultrastructure , lymphoma , lesion , gastric mucosa , mucosa associated lymphoid tissue , medicine , biology , stomach
Lymphoepithelial lesions are a characteristic feature of primary, gastric low‐grade lymphomas of mucosa‐associated lymphoid tissue (MALT). The lymphoepithelial lesions in 12 such lymphomas have been examined by electronmicroscopy and immunohistochemistry. The lymphocytes present in these lesions are neoplastic centrocyte‐like (CCL) B‐cells and are morphologically and immunophenotypically similar to those of the surrounding lymphoma. Once the CCL cells penetrate the gastric glands, there is marked structural distortion and disruption of the epithelial cells which leads to their ultimate death. The close association of the neoplastic CCL cells and epithelial cells suggests the presence of a factor, an antigen or other receptor, on the plasma membrane of the latter through which these effects are mediated.