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Stereological estimates of nuclear volume in carcinoma of the ampulla of Vater
Author(s) -
ARTACHOPERULA E.,
ROLDANVILLALOBOS R.,
LOPEZRUBIO F.,
VAAMONDELEMOS R.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb00382.x
Subject(s) - ampulla of vater , stereology , ampulla , medicine , carcinoma , nuclear medicine , pathology
The stereological estimate of mean nuclear volume is an objective and reproducible method of measurement of nuclear size in terms of absolute volume. We have used this method to study carcinomas of the ampulla of Vater. Our study includes 21 cases—five papillary and 16 intestinal—all treated by the same surgical procedure. The volumeweighted mean nuclear volume ( nuclear v̄ v ) and the mean nuclear area were calculated. The mean volumes of nuclear v̄ v were significantly different ( P <0.01) between the papillary and intestinal carcinomas, but no differences were found between normal mucosa and papillary carcinoma. The variance was significantly larger in the intestinal group than the papillary and normal groups. The nuclear v̄ v showed a significant association with survival, larger nuclear v̄ v (>150 μm 3 ) being associated with a lower survival rate.