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Cytokeratin expression in mucinous sweat gland carcinomas: an immunohistochemical analysis of four cases
Author(s) -
ECKERT F.,
SCHMID U.,
HARDMEIER T.,
ALTMANNSBERGER M.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb00365.x
Subject(s) - sweat gland , cytokeratin , pathology , immunohistochemistry , eccrine sweat gland , carcinoma , stain , monoclonal antibody , mucinous carcinoma , adenocarcinoma , antibody , biology , medicine , staining , cancer , sweat , immunology
Four mucinous sweat gland carcinomas were examined for the distribution of cytokeratin (CK) polypeptides using immunohistochemical techniques on paraffin‐embedded sections. All the tumour specimens reacted with monoclonal antibodies to CK 7, CK 8, CK 18 and CK 19. Antibodies to CK 1, CK 1/2/10/14, CK 1/5/10/11, CK 13, CK 14 and CK 20 did not stain any of the carcinomas. The results add additional support to the notion that mucinous sweat gland carcinoma represents a tumour histogenetically related to the eccrine secretory coil. Furthermore, the absence of CK 20 might significantly contribute to the differentiation of this tumour from cutaneous metastases from gastrointestinal carcinomas.