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Localized amyloidosis of the lower genitourinary tract: a clinicopathological and immunohistochemical study of nine cases
Author(s) -
KHAN S.M.,
BIRCH P.J.,
BASS P.S.,
WILLIAMS J.H.,
THEAKER J.M.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb00362.x
Subject(s) - pathology , immunoperoxidase , amyloidosis , genitourinary system , immunohistochemistry , medicine , histiocyte , amyloid (mycology) , cystoscopy , antibody , monoclonal antibody , immunology , alternative medicine
A series of nine cases of localized amyloidosis of the lower genitourinary tract are reported. The patients comprised six males and three females with an age range of 50‐79 years at initial presentation. Clinically and on cystoscopy, the lesions were often diagnosed as neoplasms. Histologically, seven cases had typical features of localized amyloid deposits, while two cases had an unusual appearance with a florid histiocytic and giant cell reaction. Using an immunoperoxidase staining method the deposits were non‐reactive with antibodies to serum amyloid A protein, prealbumin and β 2 microglobulin, while equivocal immunoreactivity was seen with anti‐light chain antibodies.