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The expression of the EBV latent membrane protein (LMP‐1) is independent of CD23 and bcl‐2 in Reed‐Sternberg cells in Hodgkin's disease
Author(s) -
ARMSTRONG A.A.,
GALLAGHER A.,
KRAJEWSKI A.S.,
JONES D.B.,
WILKINS B.S.,
ONIONS D.E.,
JARRETT R.F.
Publication year - 1992
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1992.tb00346.x
Subject(s) - cd23 , immunohistochemistry , reed–sternberg cell , lymphoma , pathology , disease , biology , downregulation and upregulation , antibody , gene , immunology , medicine , genetics , hodgkin lymphoma , immunoglobulin e
A series of 33 cases of Hodgkin's disease was investigated for the presence of the EBV encoded latent gene product LMP‐1 and of CD23 using immunohistochemical techniques. The expression of bcl‐2 was examined in a subset of cases. LMP‐1 was detected in the Reed‐Sternberg cells in 15 cases. Although LMP‐1 is known to upregulate CD23 and bcl‐2, there was no correlation between the expression of LMP‐1 and the detection of CD23 and bcl‐2 in Reed‐Sternberg cells.