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Calcium pyrophosphate dihydrate deposition disease: morphological and microanalytical features
Author(s) -
KEEN C.E.,
CROCKER P.R.,
BRADY K.,
HASAN N.,
LEVISON D.A.
Publication year - 1991
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1991.tb01501.x
Subject(s) - chondrocalcinosis , pyrophosphate , birefringence , pseudogout , calcium , calcium pyrophosphate , chemistry , crystal (programming language) , mineralogy , crystallography , pathology , medicine , biochemistry , optics , enzyme , alternative medicine , physics , programming language , organic chemistry , computer science , gout , osteoarthritis
The light microscopic and polarization appearances of calcium pyrophosphate dihydrate crystal deposits in tissues are reviewed. In routine sections haematoxylinophilic crystalline deposits with a feathery or brush‐like pattern are typical of calcium pyrophosphate dihydrate. Short rhomboidal crystals showing positive birefringence are seen on polarizaition; X‐ray microanalytical and infrared spectroscopic data support the specificity of these appearances. The appcai ances of the crystal deposits in decalcified specimens are also described. We include six cases of calcium pyrophosphate dihydrate deposition within periarticular bone; to the best of our knowledge this has not previously been described.