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Thick malignant melanomas (> 3 mm Breslow) with good clinical outcome: a histological study and survival analysis
Author(s) -
BLESSING K.,
MCLAREN K.M.,
MCLEAN A.,
DAVIDSON P.
Publication year - 1991
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1991.tb01456.x
Subject(s) - breslow thickness , medicine , melanoma , metastasis , distant metastasis , surgical margin , pathology , cancer , sentinel lymph node , cancer research , breast cancer
Thick malignant melanomas in general tend to have a poor prognosis, but exceptions occur where there may be no further recurrence. The reasons for this difference in clinical behaviour are not fully understood. We have looked at thick malignant melanomas (> 3.0 mm) in the East of Scotland that have no evidence of metastasis after a minimum of 6 years follow‐up and compared the clinical and histological features with a similar group, associated with histological evidence of metastasis and/or death. Both groups received similar treatment regimes. We have identified 41 patients with thick melanomas in the former group. When compared with the control group, factors found to be significantly different between the two groups were: the nature of the lower margin of the tumour; vascular invasion; and anatomical location.