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Peripheral T‐cell lymphomas: an evaluation of reproducibility of the updated Kiel classification
Author(s) -
HASTRUP N.,
HAMILTONDUTOIT S.,
RALFKIAER E.,
PALLESEN G.
Publication year - 1991
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1991.tb01451.x
Subject(s) - reproducibility , haematoxylin , medicine , lymphoma , peripheral , kappa , peripheral t cell lymphoma , pathology , working formulation , t cell , non hodgkin's lymphoma , immunohistochemistry , immunology , mathematics , geometry , immune system , statistics
Haematoxylin and eosin, and Giemsa stained sections from 100 peripheral T‐cell lymphomas were examined blind on two occasions by four experienced haematopathologists in order to evaluate the inter‐ and intra‐observer reproducibility of the updated Kiel classification for these malignancies. In all cases, the T‐cell phenotype had been established previously in frozen section using a panel of monoclonal antibodies. Analysis by kappa statistics showed poor reproducibility, both overall and for most subtypes, with the exception of large cell anaplastic lymphoma. The distinction between low‐ and high‐grade lymphomas was also unsatisfactory. These results indicate the need for improved precision in the definition of histological categories of peripheral T‐cell lymphoma. The reproducibility of the updated Kiel classification for peripheral T‐cell lymphomas in its present form is inadequate.