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Extramammary Paget's disease of the vulva with dermal invasion and vulval intra‐epithelial neoplasia
Author(s) -
HAWLEY I. C.,
HUSAIN F.,
PRYSEDAVIES J.
Publication year - 1991
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1991.tb00864.x
Subject(s) - vulva , extramammary paget's disease , pathology , paget disease , medicine , vulvar neoplasm , dermatology , disease , biology
Vulval biopsies from a 66‐year‐old lady complaining of pruritus showed intraepithelial Paget's disease. On simple vulvectomy, extramammary Paget's disease was found to be associated with vulval intra‐epithelial neoplasia (VIN III) and superficial dermal invasive adenocarcinoma. Bilateral inguinal lymphadenectomy later revealed metastatic spread of the tumour. We believe this is a unique combination and discuss the possible origins in relation to this lady's past medical history of breast carcinoma 20 years and spinal metastases 17 years before.