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Keratinocyte expression of intercellular adhesion molecule 1 (ICAM‐1) correlated with infiltration of lymphocyte function associated antigen 1 (LFA‐1) positive cells in evolving allergic contact dermatitis reactions
Author(s) -
GARIOCH J.J.,
MACKIE R.M.,
CAMPBELL I.,
FORSYTH A.
Publication year - 1991
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1991.tb00050.x
Subject(s) - dermis , icam 1 , intercellular adhesion molecule 1 , lymphocyte function associated antigen 1 , cell adhesion molecule , allergic contact dermatitis , epidermis (zoology) , contact dermatitis , vcam 1 , infiltration (hvac) , lymphocyte , chemistry , intercellular adhesion molecule , antigen , immunology , keratinocyte , cell adhesion , microbiology and biotechnology , biology , adhesion , pathology , medicine , in vitro , allergy , anatomy , biochemistry , materials science , organic chemistry , composite material
Adhesion molecules are considered to have an important role in inflammatory reactions. We investigated the kinetics of ICAM‐1 expression on keratinocytes and correlated this with the numbers of lymphocytes expressing LFA‐1 in the dermis and epidermis of evolving allergic contact dermatitis reactions. In nickel‐sensitive individuals, after application of a nickel patch, increased expression of ICAM‐1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA‐1 in the dermis and epidermis was greatest at 48 h. The LFA cells were observed to be in close proximity to keratinocytes expressing ICAM‐1, thus supporting the hypothesis that T‐lymphocytes attach to keratinocytes via LFA‐1/ICAM‐1 molecules.