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Spindle cell carcinoma of the breast
Author(s) -
RAJU G.C.,
WEE A.
Publication year - 1990
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1990.tb01551.x
Subject(s) - myoepithelial cell , cytokeratin , vimentin , pathology , spindle cell carcinoma , metaplastic carcinoma , immunocytochemistry , hyperplasia , cell , carcinoma , cytoplasm , breast carcinoma , biology , immunohistochemistry , medicine , microbiology and biotechnology , breast cancer , cancer , genetics
A case of spindle cell carcinoma of the breast in association with myoepithelial cell hyperplasia is presented. Immunocytochemistry demonstrated labelling of tumour cells for cytokeratin, vimentin and S‐100 protein. Electronmicroscopy showed desmosomes and bundles of tonofilaments as well as fine in in the cytoplasm. The findings in the present case point to the metaplastic spindle cell nature of squamous carcinoma of the breast. The possible role of myoepithelial cells in the origin of the spindle cell component is discussed.