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Expression of insulin‐like growth factor 1 in sarcomas
Author(s) -
ROHOLL P.J.M.,
SKOTTNER A.,
PRINSEN I.,
LIPS C.J.M.,
OTTER W. DEN,
UNNIK J.A.M.
Publication year - 1990
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1990.tb01544.x
Subject(s) - pathology , synovial sarcoma , angiosarcoma , sarcoma , fibromatosis , biology , growth factor , immunohistochemistry , medicine , receptor , biochemistry
The expression of insulin‐like growth factor‐1 (IGF‐1) was studied in normal tissues, in eight benign lesions and in 50 sarcomas. In palmar fibromatosis the spindle cells in cell‐dense areas exhibited a strong immunoreactivity. IGF‐1 was variably found in leiomyosarcomas (7/8), malignant schwannomas (7/9), synovial sarcomas (2/3), liposarcomas (3/6), fibrosarcomas (1/3), malignant fibrous histiocytomas (10/18) and in one angiosarcoma. Two rhabdomyosarcomas failed to express IGF‐1 and only the spindle cell component of synovial sarcomas was positive. Immunoreactivity for IGF‐1 in 10 malignant filrous histiocytomas (MFH) appeared to be related to co‐expression of smooth muscle actin. These findings imply that MFHs can be subdivided into a group of tumours which are devoid of morphological and immunophenotypic evidence of differentiation and a group which manifest immunophenotypic differentiation.