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Small pulmonary arterial vessels of Aymara Indians from the Bolivian Andes
Author(s) -
HEATH D.,
WILLIAMS D.,
RIOSDALENZ J.,
CALDERON M.,
GOSNEY J.
Publication year - 1990
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1990.tb01161.x
Subject(s) - hypoxic pulmonary vasoconstriction , hypoxia (environmental) , vasoconstriction , smooth muscle , pulmonary vasculature , medicine , lung , effects of high altitude on humans , anatomy , pathology , cardiology , oxygen , chemistry , organic chemistry
A study was made of the qualitative histological features of the small pulmonary arterial vessels of 25 adult citizens of La Paz, Bolivia (altitude 3600 m) coming to necropsy. Abnormalities found included muscularization of pulmonary arterioles, the development of longitudinal muscle in the intima of pulmonary arteries and arterioles, and the formation of muscular tubes lining the longitudinal muscle which extended through arterioles into the precapillaries of the lung. Arteriolar muscularization was found in three of the 13 Aymaras and in two of the 12 Mestizos studied. Intimal longitudinal muscle was present in four Aymaras and five Mestizos. Muscular tubes were found in only one case, a young Aymara. The features were very similar to those found in chronic obstructive airways disease. The appearances are consistent with a growth of new vascular smooth muscle in response to alveolar hypoxia as opposed to hypoxic vasoconstriction.