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Cytokeratin expression in chondroblastomas
Author(s) -
SEMMELINK H.J.F.,
PRUSZCZYNSKI M.,
TILBURG A. WIERSMAV.,
SMEDTS F.,
RAMAEKERS F.C.S.
Publication year - 1990
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1990.tb01112.x
Subject(s) - cytokeratin , immunohistochemistry , enolase , pathology , vimentin , polyclonal antibodies , metastasis , biology , lung , antibody , medicine , immunology , cancer , genetics
The present study is based on the histopathological and immunohistochemical examination of seven chondroblastomas, including one lung metastasis occurring 9 years after treatment. Chondroblastomas were shown to co‐express vimentin, S‐100 protein, neuron‐specific enolase, and the epithelial markers recognized by CAM 5.2, EMA and a polyclonal cytokeratin antibody. The cytokeratins present in the tumour cells of the lung metastasis were characterized as cytokeratins 8, 18, 19 and, to a lesser extent, cytokeratin 7. The results suggest aberrant cytokeratin expression in chrondroblastomas.