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A case of primary osseous malignant immunoblastic B‐cell lymphoma with intracytoplasmic mu lambda immunoglobulin inclusions
Author(s) -
FICHE M.,
TOURNEAU A.Le,
AUDOUIN J.,
TOUZARD R.R.,
DIEBOLD J.
Publication year - 1990
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1990.tb01085.x
Subject(s) - lymphoma , pathology , malignancy , antibody , population , medicine , immunohistochemistry , immunology , environmental health
Primary malignant lymphoma of bone, so‐called Parker‐Jackson reticulosarcoma, is a rare form of extranodal lymphoma with a relatively good prognosis. It often corresponds to B‐cell lymphoma of high‐grade malignancy. We report a case of mu lambda immunoblastic lymphoma showing two distinctive features: an abundant reactive T‐lymphocytic population and unusual intra‐cytoplasmic inclusions. These inclusions were PAS positive and consisted of monotypic mu lambda immunoglobulin localized in peculiar aggregates of rough endoplasmic reticulum. Their morphological appearances resembled the well‐documented inclusions described in some varieties of non‐Hodgkin's lymphoma.