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Transitional cell carcinoma of the urinary bladder with osteoclast‐type giant cells: a report of two cases and review of the literature
Author(s) -
ZUKERBERG L.R.,
ARMIN A.R.,
PISHARODI L.,
YOUNG R.H.
Publication year - 1990
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1990.tb00760.x
Subject(s) - giant cell , pathology , cystectomy , osteoclast , vimentin , transitional cell carcinoma , urinary bladder , carcinoma , cytokeratin , giant cell tumors , biology , medicine , immunohistochemistry , cancer , bladder cancer , receptor
We report two transitional cell carcinomas of the urinary bladder containing numerous osteoclast‐type giant cells that stained for vimentin and acid phosphatase (with and without tartrate) and were negative for cytokeratin and lysozyme. One tumour, in a 65‐year‐old man, was composed of papillary transitional cell carcinoma, invasive poorly differentiated carcinoma with a prominent spindle cell component and numerous osteoclast‐type giant cells; repeat curettage 2 months later showed no residual tumour. The second tumour occurred in a 75‐year‐old woman who underwent a radical cystectomy for a deeply invasive transitional cell carcinoma with a spindle and anaplastic giant cell component and areas containing numerous osteoclast‐type giant cells. Osteoclast‐type giant cells, which appear to be reactive, should be distinguished from the neoplastic giant cells of giant cell carcinoma.