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Clear cell basal cell carcinoma
Author(s) -
STARINK T.M.,
BLOMJOUS C.E.M.,
STOOF T.J.,
LINDEN J.C. VAN DER
Publication year - 1990
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1990.tb00759.x
Subject(s) - pagetoid , pathology , epidermis (zoology) , basal cell carcinoma , biology , lesion , cytoplasm , immunohistochemistry , cell , vacuole , anatomy , carcinoma , basal cell , microbiology and biotechnology , medicine , genetics
We describe a case of clear cell basal cell carcinoma of the superficial type, presenting as a crusted eruption on the abdomen. Histological examination showed a solid proliferation of clear cells attached to the under‐surface of an atrophied epidermis. In addition, distinct pagetoid infiltration was seen within the overlying epidermis. A focal connection between the clear cell portion and a deeper lying nodular basal cell carcinoma was demonstrated, elucidating the true nature of the lesion. Immunohistochemical studies and electronmicroscopy confirmed the epithelial derivation of the tumour. The clear cell appearance was due to multiple cytoplasmic electronlucent vacuoles which were not surrounded by membranes.