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Pulmonary blastoma with neuroendocrine differentiation in cell morules resembling neuroepithelial bodies
Author(s) -
CHEJFEC G.,
COSNOW I.,
GOULD N.S.,
HUSAIN A.N.,
GOULD V.E.
Publication year - 1990
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1990.tb00740.x
Subject(s) - pulmonary blastoma , synaptophysin , chromogranin a , pathology , neuroendocrine differentiation , enolase , stromal cell , biology , neuroepithelial cell , immunohistochemistry , cellular differentiation , lung , microbiology and biotechnology , medicine , stem cell , biochemistry , prostate cancer , cancer , neural stem cell , genetics , gene
Pulmonary blastoma is an infrequent malignant neoplasm, so called because of its resemblance to fetal lung. The original description outlined the components as variable mixtures of epithelial and stromal elements. More recently, a variant displaying almost exclusively epithelial differentiation has been described. We report our findings in a case of pulmonary blastoma with predominance of epithelial cells, forming tubular structures and large morules. The architectural arrangement of the morules was remarkably similar to normal bronchial neuroepithelial bodies. Moreover, their immunohistochemical profiles were also very similar, including the expression of cytokeratins, chromogranin, neuron‐specific enolase, synaptophysin, gastrin, calcitonin, bombesin, somatostatin and serotonin.